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The bus station (Tsukuba Center) in Tsukuba is opposite Tsukuba Station. Both local and highway buses depart from Tsukuba Center. The ticket office also serves as the Tourist Information Center.

Local buses are operated by Kanto Tetsudo (Kantetsu) and run to Tsuchiura Station in Tsuchiura, Mt. Tsukuba, Wellness Park, Hitachi-no-Ushiku Station, Ushiku Station, Kenkyugakuen Station, Sakura Newtown, Tenchnopark-oho, Tsukuba University Hospital, Driving License Center, Shimotsuma Station, Ishige Station, Aeon Mall Tsukuba, Kenchikukenkyujo, Space Center (Uchu Senta-) and Daigaku Nishi.

There are also long-distance highway buses to Tokyo (via Ueno Station to Tokyo Station 90 minutes), Narita and Haneda airports (both airports about 1 hour 40 minutes) and Mito Station in Mito.
Buses to Tokyo DisneySea and Tokyo Disneyland begin at Tsuchiura Station and call at Tsukuba Center on the way. There are 3 buses daily from Tsukuba at 6.30am, 7.50am and 3.20pm (95 minutes; 1,540 yen).

There are overnight buses to Osaka (Dream Go; 9,900 yen), Kyoto (Yokappe Go; 9,100 yen) and Nagoya.

Kantetsu buses to Kyoto and Osaka start at Mito Station South Exit, call at Tsuchiura Station, Kyoto Station Hachijoguchi Exit, Osaka Station, Namba Station West Exit (OCAT) and Abeno Harukas. The bus departs at 10.53pm from Tsukuba Center arriving at Kyoto Station at 6.17am and Osaka Station at 7.13am.

The last bus to Tokyo from Tsukuba Station is at 12.30am daily. The buses to Narita ...